CXCL8 and Sepsis: For instance, a study illustrates that Th1, Th2, and Th17 type cytokines, IL-6, IL-8, and IL-10 are increased but IL-12 is decreased in patients with sepsis than healthy individuals; IL-8 overexpression correlates with renal and cardiac function damage, and IL-10 is downregulated in survivors than deaths [21].