CD4 and Sepsis: Thus given the regulatory roles of JKAP, Th1 cell and Th17 cell in sepsis, along with the modulating role of JKAP in CD4+ T cell activation and differentiation to Th1 or Th17 cell, we presumed that JKAP may be correlated with the Th1 cell or Th17 cell proportion in sepsis patients, and the three of them possibly have potential assisting in the management of sepsis.