In another study, serum JKAP expression is declined in Crohn’s disease (CD) patients compared with healthy individuals, and its overexpression associates with lower CD risk, activity, pro-inflammatory cytokines levels; more interestingly, serum JKAP overexpression is also an independent factor for predicting unfavorable response to TNF-α inhibitor in CD patients [7]. Here, TNF is linked to Crohn disease.