Our data showed that (i) JKAP was downregulated but Th1 and Th17 cell proportions were upregulated in sepsis patients compared with controls, and JKAP was negatively correlated with Th1 and Th17 cell proportions in sepsis patients; (ii) JKAP was negatively associated with pro-inflammatory cytokines and disease severity in sepsis patients; (iii) JKAP level and Th17 cell proportion were independent predictive factors for 28-day mortality in sepsis patients. The gene discussed is DUSP22; the disease is Sepsis.