The effects observed following ITGB3 knockdown in vitro and in vivo can be explained by downregulation of specific genes, which have roles in angiogenesis (NPTN, RRM2) (Rodriguez-Pinto et al. 2009; Chen et al. 2019), tumor growth (NPTN) (Rodriguez-Pinto et al. 2009), energy metabolism (ISCA1) (Yang et al. 2019), cytokinesis (SEPT11) (Hanai et al. 2004), migration (RRM2, STX6) (Chen et al. 2019; Zhu et al. 2016), cell proliferation, invasiveness, senescence, tumorigenesis (RRM2) (Chen et al. 2019) and vesicle trafficking (SEPT11, STX6) (Hanai et al. 2004; Zhu et al. 2016). This evidence concerns the gene RRM2 and neoplasm.