As integrins are known as adhesion-mediating molecules (Hamidi et al. 2016), we suggest that ITGB3 plays a role in the adhesion of the tumor-derived exosomes to their target cells of the pre-metastatic niche, which is an important step that enables the horizontal transfer of other biomolecules from these exosomes to their target cells. This evidence concerns the gene ITGB3 and neoplasm.