Expression of phosphoinositide 3-kinase (PI3K), protein kinase B (Akt), multidrug resistance gene 1 (MDR1) and multidrug resistance-related protein 1 (MRP1) in tumor tissue injected with SKOV3/DDP cells was higher than that in tumor tissue injected with SKOV3 cells (expression of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) was lower). This evidence concerns the gene AKT1 and neoplasm.