Some instances where we have observed high antibodies to some of the glycans are HIV infected patients (antibodies to Man9, GT2, and GT3)66 and cancer patients immunized with a whole cell cancer vaccine (antibodies to GM2, GM3, Gb5, and sialyl Lewis X).67 In these cases, antibodies to self-glycans were present in fewer patients and for fewer glycans than what we observed in COVID-19 patients. This evidence concerns the gene MAN1A1 and cancer.