Expression of PFKFB3 is not typical of liver tissue; however, this isoform is also known as inducible PFKFB, as it has been observed to be expressed in response to hypoxic conditions of cancer cells by hypoxia inducible factor 1-alpha (HIF1α) (Bando et al., 2005; Shi et al., 2017). The gene discussed is HIF1A; the disease is cancer.