Massively parallel sequencing studies by our group and others have revealed that some histologic special types of BC are underpinned by highly recurrent or even pathognomonic genetic alterations, including ETV6-NTRK3 fusion gene in secretory carcinoma, and MYB/MYBL1 rearrangements or MYB amplification in adenoid cystic carcinoma2,12–14. This evidence concerns the gene MYB and breast cancer.