The heatmap visualization of the 26 pre-defined (qualifying)AKT-mTOR-HER family signaling proteins/phospho-proteins assayed from pretreatment,LCM-purified tumor epithelium (Fig. 3a)shows tight co-clustering of total ERBB2 protein and phospho-proteins ERBB2 Y1248and SHC Y317, which are most highly expressed within the HER2+ subset. Here, SHC1 is linked to neoplasm.