In this study, enrichment analysis was performed, which revealed the functions and pathways of JAK3 and TYK2 in STAD, indicating that JAK3 and TYK2 were mainly associated with adaptive immune responses, translational initiations, DNA damage responses, chemokine signaling pathway, NF-kappa B signaling pathway, ribosomal structure, and JAK-STAT signaling pathway. Here, JAK3 is linked to gastric adenocarcinoma.