There were previous studies that show evidence for the relationship with AD, such as ACTA2, TGFBR2, FBN1, MMP2, MMP9, MYLK, TGFB1, COL3A1, IL6R, AR, CREBBP, LRP1, and THBS1. MLX, DAB2IP, EP300, ZFYVE9, PML, and PRKCD were newly identified to be associated with AD based on current literature retrieval and analysis. The gene discussed is MMP9; the disease is Alzheimer disease.