Hence, the INHBB gene might be involved in regulatory mechanisms of cancer through its encoded protein—activin B. Our study shows that high expression of INHBB is positively correlated with the Hedgehog signaling pathway, ECM receptor interaction, TGF-β signaling pathway, focal adhesion, and pathway in cancer which play essential roles in carcinogenesis and metastasis of CRC. The gene discussed is INHBB; the disease is cancer.