Univariate analysis demonstrated that high expression of INHBB (P < 0.001), age (P = 0.002), invasion depth (P < 0.001), lymph node metastasis (P < 0.001), distant metastasis (P < 0.001), and TNM stage (P < 0.001) corresponded with poor OS in CRC patients. The gene discussed is INHBB; the disease is metastatic malignant neoplasm in the lymph nodes.