In the present research, the expression of TPPP3 in nasopharyngeal carcinoma (NPC) tissues was detected in 57 cases of NPC and 30 cases of normal tissue by immunohistochemistry, and the relationship between TPPP3 and clinicopathological features of NPC was analyzed at the same time. The gene discussed is TPPP3; the disease is nasopharyngeal carcinoma.