Although beyond the scope of the present study, further work using ULK1 inhibitors in animal models of hypercholesterolemia or carcinogenesis may be useful to test the translational value of ULK1 inhibitors, either alone or as an adjunct with statins, for the protection or treatment of diseases associated with deranged cholesterol synthesis. The gene discussed is ULK1; the disease is familial hypercholesterolemia.