Pearson correlation analysis showed that LncRNA H19 was negatively correlated with bone metabolism indexes PINP, N-MID, BGP, BALP and Lysholm score (<i>P</i><0.05), and positively correlated with bone metabolism indexes β-CTX, VAS score and WOMAC score (<i>P</i><0.05).<h4>Conclusion</h4>LncRNA H19 is highly expressed in peripheral blood of patients with osteoarthritis, which is closely related to the occurrence and development of osteoarthritis and has a good diagnostic value for osteoarthritis. Here, H19 is linked to osteoarthritis.