Multiple candidate genes, including thrombospondin-2, vitamin D receptor, COL2A1, ACAN, interleukins (IL1α, IL 1β, and IL6), matrix metalloproteinases (MMP-3 and MMP-9), and growth/differentiation factor 5, have been associated with the pathophysiological process of IDD development (Feng, Egan & Wang, 2016; Kalb et al., 2012; Wang et al., 2018b; Yuan et al., 2018). Here, COL2A1 is linked to intervertebral disk degenerative disorder.