Additionally, some bioinformatics analyses based on gene expression profiles revealed that FYN, PRKCD, YWHAB, YWHAZ, AR, Fibronectin 1, COL2A1, β-catenin, COL6A2, IBSP, RAP1A, and FOXF2 genes may play key roles in IDD development (Chen et al., 2013; Guo et al., 2017; Ji et al., 2015). This evidence concerns the gene COL2A1 and intervertebral disk degenerative disorder.