Wiemels JL et al. identified new risk loci, located on 17q12 near Zona pellucida binding protein 2 (ZPBP2), could regulate gene expression by local interactions with ZPBP2, impacting function of hematopoietic and growth-regulation pathways in childhood acute lymphoblastic leukemia (Wiemels et al., 2018). This evidence concerns the gene ZPBP2 and acute lymphoblastic leukemia.