Also, Nitidine chloride, Berberine hydrochloride, 1β-hydroxyalantolactone, Britanin and Tanshinone IIA reversed the expression of 37, 35, 31, 30 and 19 overlapping DEGs, respectively, and the potential therapeutic effects of these ingredients on breast cancer were related to biological pathways such as Cell cycle, Oocyte meiosis, p53 signaling pathway and Progesterone-mediated oocyte maturation (Figs. 7B–7F). This evidence concerns the gene TP53 and breast cancer.