In acute heart failure, data are less clear: Legrand et al. [21] were not able to demonstrate a diagnostic role of urinary NGAL to early recognize renal injury, whereas Aghel et al. [15] revealed that admission serum NGAL levels (140 ng/ml) had a 7.4-fold increase in the risk of developing renal dysfunction; high levels are also related to poor outcome in a follow-up period. The gene discussed is LCN2; the disease is Abnormal renal physiology.