CLRN1 and Oppositional defiant disorder: The Usher syndrome patients had mutations in several Usher genes including ADGRV1, CLRN1, USH2A, CDH23, and MYO7A. Mutations in CDH23 and MYO7A were the most common in our cohort, accounting for 50% of the Usher syndrome ODD patients (Table 3).