Studies that employed genetic depletion of PYCR1 have confirmed a functional role for PYCR1 in promoting tumor progression and cancer cell survival in colorectal cancer cells104, NSCLC cells42,97,98, renal cancer cells64,103, prostate cancer cells105, and IDH1-mutant gliomas106. The gene discussed is IDH1; the disease is non-small cell lung carcinoma.