The CpG island was hypermethylated in all three breast cancer cell lines and the normal mammary epithelial cells, and there were no obvious differences in FGF14-AS2 promoter methylation levels among these cells (data not shown), suggesting that FGF14-AS2 promoter hypermethylation might not be the major reason for its dysregulation in breast cancer. This evidence concerns the gene FGF14 and breast carcinoma.