Parthenolide (PN), as a sesquiterpene lactone used for therapy of inflammation, via inhibiting canonical NF-κB (p65/p50) activation followed by direct interaction of PN with inhibitor of nuclear factor kappa-B kinase (IKK) β and subsequently suppressing IKK signalsome13,14, as well as an inductor of HDAC1 degradation by proteasome activity15 has been reported to have anti-cancer property16,17. This evidence concerns the gene NFKB1 and cancer.