HIF3A and cancer: For instance, many of the lung-specific TFs which SCIRA predicts to be inactivated in lung tumor epithelial cells (e.g., NKX2-1, FOXA2, FOXJ1, AHR, and HIF3A)30 implicate key cancer pathways (lung development, alveolarization, ciliogenesis, immune response, and hypoxia response), and their inactivation likely represent key driver events.