Unexpectedly, although baricitinib has been shown to own high affinity to AAK1, it did not display obvious inhibition on the phosphorylation of AP2M1 unless at very high dose (10 μM) (Supplementary Fig. S2a), and consequently displayed no inhibitory effect on infection of each type of pseudovirus (Supplementary Fig. S2b). Here, AP2M1 is linked to infection.