However, compared with HeLa cells expressing wild-type ACE2 (ACE2-HeLa), the sensitivity of mACE2-HeLa cells to HIV/SARS-CoV or HIV/SARS-CoV-2 infection was significantly reduced, but the susceptibility to HIV/AMLV did not change (Fig. 1h), suggesting that the potential interaction between AP2M1 and YASI motif in ACE2 plays an important role during the entry of SARS-CoV and SARS-CoV-2 into host cells. Here, ACE2 is linked to infection.