Spearman's rank correlation showed significant negative correlations between catestatin assessed after sub- and maximal physical exertion in the study group of patients and biomarkers with an established position in modern cardiology (CST post vs. NT-proBNPpre, r = −0.18; CST post vs. TnTpre, r = −0.33; CST post vs. TnT post, r = −0.24) and no significant correlation between traditional diagnostic and prognostic markers used in HF, such as hs-CRP and NT-proBNP, and plasma CST concentration evaluated before physical exertion. The gene discussed is NPPB; the disease is hydrops fetalis.