We found that the baseline CHI3L1 level significantly decreased compared with that immediately after treatment in the LC group receiving DAA treatments and continued to decrease at a much slower pace immediately after treatment, and it was still markedly reduced at week 24 or week 48 posttreatment, suggesting that even for LC patients, CHI3L1 can sensitively detect early and small changes in liver fibrosis after treatment for the LC patients, a task not easily achievable with less sensitive technologies such as FibroScan. Here, CHI3L1 is linked to laryngotracheoesophageal cleft.