Rath et al. found that of all serum markers analyzed, including CHI3L1, HA, LN, CIV, matrix metalloproteinase 9 (MMP-9), tissue inhibitors of metalloproteinases 1 (TIMP-1), tissue inhibitors of metalloproteinases 2 (TIMP-2), and a complex of MMP-9 and TIMP-1, CHI3L1 exhibited the highest diagnostic accuracy in the total patient population as well as in the subgroup of patients with HCV-associated liver disease [20]. This evidence concerns the gene TIMP1 and liver disorder.