We obtained 251 potential therapeutic targets of COVID-19 from the GeneCards database (Supplementary file, Table S3), 119 therapeutic targets were obtained from the systemic literature search (Supplementary file, Table S4) and Single-cell sequencing was used to obtain 3525 gene targets that were co-expressed with ACE (Supplementary file, Table S5). The gene discussed is ACE; the disease is COVID-19.