With regard to effector targets, the degree values of GAPDH, albumin (ALB), TNF, EGFR, MAPK1, CASP3, STAT3, MAPK8, PTGS2, JUN, IL-2, Estrogen Receptor 1 (ESR1), and MAPK14 were all > 40, suggesting that in COVID-19 these could be the main therapeutic targets of XBJ’s active ingredients. The gene discussed is ESR1; the disease is COVID-19.