KNG1 and cancer: Apart from inflammation, BK also has a role in tumour progression, as evident by the expression of BKB1R in cancers of breast, kidney, stomach, oesophagus, malignant mesothelioma, cervix, prostate and expression of BKB2R in the HNSCC (head and neck squamous cell carcinoma), osteosarcomas, cancers of endometrium, kidney, stomach and pituitary gland [25].