Reactive oxygen species act as a second messenger that activates nuclear factor kappa B (NF-κB), necrosis factor-α (TNF-α), and interleukins (ILs) which reduces the expression of GLUT 4 and activates intracellular adhesion molecule-1 to stimulate the growth of insulin resistance [40–43]. This evidence concerns the gene NFKB1 and Insulin resistance.