HIF1A and retinal ischemia: Compared with the normal control (normalized to 1; n = 3∼4; Figures 5(b)∼5(d)), there was a significant (P < 0.01/0.05) upregulation of target proteins, namely, Wnt3a (6.72 ± 1.32; n = 3; Figure 5(b)), HIF-1α (11.75 ± 4.80; n = 4; Figure 5(c)), and VEGF (6.82 ± 1.69; n = 4: Figure 5(d)) induced by retinal ischemia (Vehicle + I/R).