For example, miR-15a and miR-16-1 induce apoptosis in chronic lymphoblastic leukemia (CLL) by targeting anti-apoptotic factors such as Bcl2 and BAD (45), while miR-155 inhibits apoptosis by targeting Fas-associated death domain-containing protein (FADD), caspase 3 and caspase 7 (46). This evidence concerns the gene CASP3 and B-cell chronic lymphocytic leukemia.