IFNG and macrophage activation syndrome: Elevation of Th1 cytokine interferon (IFN)-gamma; inflammatory cytokines interleukin (IL)-1, IL-6, and IL-12; neutrophil chemokine IL-8; monocyte chemoattractant protein-1 (MCP-1); and Th1 chemokine IFN-gamma-inducible protein-1 [2] leads to a cytokine storm (CS) called macrophage activation syndrome (MAS) or secondary haemophagocytic lymphohistiocytosis (sHLH), which causes tissue damage [3].