In our study, results showed that bergamot essential oil, bergamot juice, sweet orange essential oil, and sweet orange juice could reduce the levels of IL-6, TNF-α, MMP-2, MMP-9, and especially IL-1α, indicating that bergamot essential oil, bergamot juice, sweet orange essential oil, and sweet orange juice could improve acne vulgaris through alleviating inflammatory response and suppressing P. acnes in golden hamsters (Figures 4 and 5). The gene discussed is MMP2; the disease is acne.