PRTN3 and osteoarthritis: Therefore, to gain insight into trained immunity with tissue heterogeneity, we defined the top 100 upregulated genes in the Mo(cIgG) as cIgG-trained signatures via RNA sequencing (Figure 3(a) and Supplementary Table 2) and ran the three pathotype signatures in GSEA against synovial tissues [27] from healthy individuals (n = 28) and patients with osteoarthritis (n = 22), ACPA-positive arthralgia (n = 10), undifferentiated arthritis (n = 6), early RA (n = 57), and established RA (n = 95) (Figure 5(a)).