In the TUBB2B cohort, heterotopic neurons (83.3%), enlarged germinal zones (66.7%), and neuroglial overmigration (50.0%) were described, with neuroglial overmigration being a distinctive histopathological feature in TUBB2B tubulinopathy (9.5% vs. 50.0%; P = 0.024). Here, TUBB2B is linked to tubulinopathy.