Our clinical data suggest a generally milder course of TUBB2B compared with TUBA1A tubulinopathy regarding the time course of estimated survival and the less frequent occurrence of neurological comorbidities such as motor impairment (97.3% vs. 73.1%), abnormalities of the muscular tone (89.6% vs. 48.0%), and global developmental delay (95.7% vs. 76.7%). The gene discussed is TUBB2B; the disease is Global developmental delay.