It should be noted that although we saw a clear reduction in EGFR phosphorylation and expression post TMZ and irradiation treatment and thus the EGFR was the major focus of this article, there may be many other changes to the activity and expression levels of both receptor tyrosine kinase and other key molecules that predict and mediate glioblastoma cell resistance to treatment. Here, EGFR is linked to glioblastoma.