Then, to explore the protein localization and expression level of Talin1 in CRC samples as well as its correlation with clinicopathological features and survival outcome in CRC patients, the findings from the analysis of gene expression data were validated and confirmed on a large series of CRC tissue microarrays (TMAs) using the immunohistochemistry (IHC) technique. The gene discussed is TLN1; the disease is colorectal carcinoma.