Among the 25 SNVs that were detected 47 times in 33 patients with HCC (Fig. 2b), the most frequently detected were the KIT chr4:54727315A>G (rs55986963; 17%), MLH1 chr3:37025749T>A (rs63750447; 13%), STK11 chr19:1223126C>G (rs59912467; 13%), PTEN chr10:87864461C>G (rs11202592; 9%), CTNNB1 chr3:41224610C>T (rs121913400; 4%), and STK11 chr19:1207009C>G (rs79175212; 4%). This evidence concerns the gene PTEN and hepatocellular carcinoma.