To examine the roles of MUC1 and MUC4 in IL-17RB-mediated stemness in the pancreatic cancer cells, we overexpressed FLAG-tagged IL-17RB, followed by knockdown of MUC1 and MUC4 by lentivirus-based shRNA in SU.86.86 cells. This evidence concerns the gene MUC4 and familial pancreatic carcinoma.