To examine the roles of MUC1 and MUC4 in IL-17RB-mediated stemness in the pancreatic cancer cells, we overexpressed FLAG-tagged IL-17RB, followed by knockdown of MUC1 and MUC4 by lentivirus-based shRNA in SU.86.86 cells. The gene discussed is IL17RB; the disease is familial pancreatic carcinoma.