The glucose/NF546-induced spatial confinement of P2Y11/P2Y11-like/AC5-mediated cAMP is essential to facilitate activation of distinct pools of PKA that stimulate a subpopulation of L-type Ca2+ channels to increase global [Ca2+]i leading to vasoconstriction during hyperglycemia. This evidence concerns the gene ADCY5 and Hyperglycemia.