Enrichment in rounded cells (Fig. 1d) and Myosin II activity, as measured by phosphorylated MLC2 (p-MLC2) levels (Fig. 1e), were observed at the invasive front (IF) of A375M2 tumours compared with tumour body (TB), while decreased cell rounding and Myosin II levels were found in A375P tumours (Fig. 1d, e). This evidence concerns the gene MYL12B and neoplasm.