Moreover, enrichment in Myosin II activity and ki-67 positive cells was found in IFs of A375M2 tumours (Fig. 1e and Supplementary Fig. 1a, c), suggesting that the amoeboid phenotype sustained by ROCK1/2-Myosin II could, in principle, support tumour formation and tumour dissemination. Here, ROCK1 is linked to neoplasm.