Specifically, the transcriptomes of amoeboid A375M2 melanoma cells were compared to A375M2 cells treated with ROCK1/2 inhibitors (ROCKi) or blebbistatin, a direct Myosin II inhibitor, or compared to intrinsically less amoeboid and less metastatic A375P melanoma cells with lower Myosin II activity10,12,15. Here, ROCK1 is linked to melanoma.