Since the role of RhoC in STAT3 phosphorylation has not been established before in GC, we analyzed the phosphorylation of STAT3 tyr705 in the RhoC knockdown cell lines and the control and showed that there were a decrease in pSTAT3 tyr705 in the RhoC knockdown GC cell lines (Fig. 4A, B). The gene discussed is RHOC; the disease is gastric cancer.