Concerning that RFPL3 belongs to RFPL protein family that has the same structural characteristics with Ret finger proteins (RFP), such as the Ring-finger and B30.2 domains connected by coiled-coil domain, and the coiled-coil domain that has been identified to be responsible for the dot-like structure of RFPL proteins, consistently, our results uncovered the grainy pattern of RFPL3 in the cytoplasm/membrane of NSCLC cells27,37. Here, TRIM27 is linked to non-small cell lung carcinoma.