Furthermore, Other CpG loci contributing to our cortical and hippocampal clocks are proximal to the mouse orthologues of genes found to be differentially methylated in AD patients, including Bin1, Ezh1, Irx3, Rufy4, Dleu2 and Ddr1 [60, 72–74], indicating the translational potential of some of these epigenetic marks. Here, BIN1 is linked to Alzheimer disease.