Furthermore, Other CpG loci contributing to our cortical and hippocampal clocks are proximal to the mouse orthologues of genes found to be differentially methylated in AD patients, including Bin1, Ezh1, Irx3, Rufy4, Dleu2 and Ddr1 [60, 72–74], indicating the translational potential of some of these epigenetic marks. This evidence concerns the gene RUFY4 and Alzheimer disease.