These CpGs were found in clusters in the proximity of certain genes, namely 7 CpGs in Mir-219, 6 CpGs in Ntng2, 5 CpGs in Dlue2 and 2 CpGs in Coa6. For Mir-219, Ntng2 and Dlue2 methylation levels increased with age for the AD mice and decreased with age for the B6 mice. Here, COA6 is linked to Alzheimer disease.