A limited number of pathogenic POLE variants within the exonuclease domain have been identified as resulting in an ultra-mutated phenotype in endometrial cancer.40 41 Approximately 8–10% of all endometrial cancers carry one of these pathogenic POLE mutations.39 In the molecular classification of endometrial cancer these cases are referred as POLEmut. The gene discussed is POLE; the disease is endometrial cancer.