CTNNB1 and endometrial cancer: In this trial, the four molecular sub-groups are combined with other prognostic factors (substantial lymphovascular space invasion, L1-cell adhesion molecule expression, and CTNNB1 mutation) to designate favorable, intermediate, and unfavorable profile.58 Participating women with high-intermediate risk endometrial cancer are randomized (2:1) to adjuvant treatment based on their molecular-integrated risk profile or standard adjuvant vaginal brachytherapy.