ZNF154 and cancer: As shown in Fig. 3a and Additional file 1: Figure S8, preliminary meta-analysis of the methylation density profiles of EOC-positive and cancer-free women revealed that while both cohorts exhibited a large fraction of ZNF154 epialleles with little to no methylation, only cfDNA from cancer-positive patients exhibited the presence of a significant proportion of densely methylated ZNF154 epialleles.