These data indicate that the increases in the levels of p-p38, p-JNK, and p-ERK1/2 in infected dog and human brain tissues were induced by street RABV CGS-17 and CXZ-15 and that clear differences in the expression of MAPK pathway components were observed between the dog or human brain in the context of natural infection and the mouse brain in the context of artificial model infection. The gene discussed is MAPK8; the disease is infection.