In RABV infection, increases in the levels of p-p38, p-JNK, and p-ERK1/2 occur in infected dog and human brain tissues, but lower levels of MAPK phosphorylation are observed only in mouse neuronal brain cells upon infection, and only a few immunostained degenerating cells and cerebrovascular endothelial cells accumulate to low numbers in the perivascular spaces of mice infected with street RABV. Here, MAPK3 is linked to infection.