TM6SF2 and metabolic dysfunction-associated steatotic liver disease: Third, even though our ANCOVA models were adjusted for several potential confounders, the probability of residual confounding bias because of unknown or unmeasured confounding variables (e.g., genetic determinants of NAFLD including the palatin-like phospholipase domain-containing 3 or the transmembrane 6 superfamily member 2 gene polymorphism) cannot be entirely ruled out [5].