To investigate the distribution of DARP-Lip(Bn) and EC1-LoPE in tumor tissue in vivo, DARP-Lip(Bn) conjugated with Cy3 and EC1-LoPE conjugated with Cy5.5 were injected i.p. in HER2/EpCAM–overexpressing tumor-bearing athymic BALB/c Nude mice. This evidence concerns the gene EPCAM and neoplasm.