CD30 belongs to the tumor necrosis factor receptor (TNFR) superfamily [288] and, although initially described as an antigen expressed on Hodgkin ́s lymphoma (HL) cells, it was later found to be expressed in other hematological malignancies such as anaplastic large cell lymphomas (ALCL), CTCL, PTCL, adult T-cell leukemia/lymphoma, and diffuse large B cell lymphomas (DLBCL) [289,290]. The gene discussed is TNFRSF8; the disease is diffuse large B-cell lymphoma.