TRBC1 and T-cell non-Hodgkin lymphoma: Taking advantage of the mutually exclusive expression of TCRβ-chain constant domains 1 and 2 (TRBC1 and TRBC2) on mature T cells, and of the fact that about half of TCR+ T-cell lymphomas solely express TRBC1, Maciocia et al. [180] recently developed an original approach for targeting mature T-cell cancers.