In T-ALL, PDX models based on administration of anti-IL-7Rα mAbs and ADCs have provided promising results for therapeutic targeting of T-ALLs expressing either wild type or mutant IL-7Rs [251,252], and preclinical studies have also proved that mAb-mediated IL-7R targeting impairs B-ALL progression and metastasis [253]. This evidence concerns the gene IL7R and precursor B-cell acute lymphoblastic leukemia.