NPC1 and neuroblastoma: In this context, increased ROS levels were found in a number of NPC1 in vivo and in vitro models, ranging from rats treated with NPC1 inhibitor U18666A, BALB/c mice carrying either different NPC1 mutations or a knockout, a yeast homolog of a NPC1 model and CHO cells to human neuroblastoma cells and NPC1 patient-specific fibroblasts [13,14,15,16,17].